Spyse and Wulf.

FLUFF TAIL MUST BE FLOOFED

Kind-looking grey-haired dude? Check.

Orange/gold-colored fluffy fox? Check.

...huh. AU Spice & Wolf, maybe?

A game demo by a somewhat well-known NSFW game dev (of Strive for Power fame). That color scheme and fox-human partnership was pretty iconic.

FLOOFY TAIL MUST BE FLUFFED

Sources:

1. Displaced demo project by Strive4Power (NSFW)
2. Spice & Wolf anime